Enteral administration of protein supplement and valproate: A potential pharmacokinetic interaction

Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients

A randomized, double-blind, placebo-controlled cross-over study of adjuvant treatment with remacemide hydrochloride was carried out in 17 patients taking sodium valproate (VPA) as monotherapy. Plasma concentration profiles of VPA, remacemide, and its active desglycinyl metabolite (ARL12495XX) were determined following single (300 mg) and multiple dosing (150 or 300 mg twice daily) of remacemide...

Enteral feeding: techniques of administration.

The objective of nutritional support is to provide sufficient nutrients to maintain or improve nutritional state.' These aims may be difficult to achieve using enteral nutrition2 as positive nitrogen balance may not be established consistently throughout a course.3 This finding has little to do with the formulation of the diet itself as up to one third of a prescribed diet may never reach the p...

Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy.

AIM Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS Two hundred epileptic children, whose VPA serum concentrations were collected, were divided randomly into two groups (A and B, n=100 each). The PPK parame...

Gastric Emptying and Administration of Enteral Nutrition

Continuous administration of enteral lipid- and protein-rich nutrition limits inflammation in a human endotoxemia model.

OBJECTIVE An overzealous inflammatory response is an important cause of morbidity and mortality in surgical, trauma, and critically ill patients. Enteral administration of lipid-rich nutrition was previously shown to attenuate inflammation and reduce organ damage via a cholecystokinin-1 receptor-mediated vagovagal reflex in animal studies. The current preclinical study investigates the immunomo...